Nvidia Graphics Issues
In general, Nvidia graphics cards and drivers work very well with Second Life.
Mac El Capitan
There is a known Nvidia driver crash that occurs for some users on El Capitan. See Mac El Capitan Nvidia Driver Crash.
Recent Crashes on Windows, Following a Driver Update
If you have started crashing following an Nvidia driver update, try going back to the driver version that worked for you. Be sure to completely uninstall the recent driver before installing the older one.
See also this page.
Unable to Double Click
If you have Nvidia Shadowplay installed, disable it. Google “how to disable nvidia shadowplay” for instructions.
One user reports that on a recent Nvidia Experience version, turning off Share in the Settings menu disables Shadowplay without having to go through Windows controls.